PLGA Nanospheres Loaded with Autoclaved Leishmania Major (ALM) and CpG-ODN: Preparation and in vitro Characterization

fa 1608-6015 PLGA Nanospheres Loaded with Autoclaved Leishmania Major (ALM) and CpG-ODN: Preparation and in vitro Characterization Seizure Characteristics in Patients with Seizure Attacks Objective(s)Several antigens, adjuvants and delivery systems have been evaluated for induction of protective immune responses against Leishmaniasis, but most of them have been inefficient. In this study, PLGA nanospheres as antigen delivery system CpG-ODN as an immunoadjuvant for increasing the immune responses against Autoclaved Leishmania major (ALM) were prepared and characterized. Leishmania major, CpG-ODN, PLGA nanosphere, Vaccine Mohsen Tafaghodi School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran email: tafaghodim@mums.ac.ir No Abolghasem Sajadi Tabassi School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran No Nafiseh Amiri School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran No