Dr. Jalil Tavakol Afshari   tavakolaj@mums.ac.ir Address: Bu Ali Research Institute Immunogenetic & Tissue Cultlure Dept. Mashhad University of Medical Sciences (MUMS) Bu-Ali research center, Bu-Ali square, Mashhad - IRAN Tel: +98 511 7112471 Fax: +98 511 7112596 Education Thesis Appointments and Professional Honors and Awards Research Experience Research Interests Licensure Professional Societies Publications Mosaffa, F., Lage, H.,Tavakol Afshari, J., Behravan, J. Interleukin-1 beta and tumor necrosis factor-alpha increase ABCG2 expression in MCF-7 breast carcinoma cell line and its mitoxantrone-resistant derivative, MCF-7/MX. In Press. Inflamm. Res. Published on line 31 March 2009. Kiani, Z., Tavakkol-Afshari, J., Hojjat, H., Arab, HR., Radvar, M., Sadeghizadeh, M. and Ebadian, AR. Polymorhism of IL-1 alpha (-889) Gene and its Association with Aggressive periodontitis. IJAAI, 2009, 8(2), 95-98. Mousavi, SH., Tavakkol Afshari, J., Brook, A. and Jafari-Anarkooli, I. Role of caspases and Bax protein in saffron-induced apoptosis in MCF-7. Food and Chemical Toxicology, 2009, 47(8), 1909-1913. Abbasi, M., Rezaeiyazdi, Z., Tavakkol Afshari, J., Hatef, MR., Sahebary, M. and Yarjanli, M. Vitamin D receptor polymorphism in patients with Systemic Lupus Erythomatosus. The Journal of Qazvin University of Medical Sciences, 2009, 13(1), 29-33. Mousavi, SH., Tavakkol Afshari, J., Brook A. and Jafari-Anarkooli, I.  Direct toxicity of rose bengal in MCF-7 cell line: Role of apoptosis. Food and Chemical Toxicology, 2009, 47(4):855-859. Mousavi, SH., Tavakkol Afshari, J., Brook, A. Study of cytotoxic effects of Saffron in MCF-7 cells. Iranian Journal of Pharmaceutical Sciences (IJPS), 2008, 4(4), 263-268. MirMotalebi, F., Malekzadeh, F., Tavakol Afshari, J. and Nazari, S. Comparison of cytotoxicity of three dentin bonding systems with two thicknesses of dentin barrier on L929 cell line. Iranian Indoontic Journal. Fall 2008, 3 (4), 118. Tavakkol Afshari, J., Hajzadeh, M.A.R. and Barati, M. Effects of Aqueous Extract of Alpinia Galanga on Proliferation of HT29 and L929 Cell Lines In Vitro. J. North Khorasan U. Medical Sciences, 2008, No.1, Autumn; 47-58. Shahrokhabadi K., Afshari RT., Alizade H., Afshari JT., Javadi GR. Identification of DREB Homologous Genes in Bread Wheat via CODEHOP PCR Primer Design. Pakistan Journal of Biological Sciences, 2008, 11(16): 1979-1986. Tavakkol Afshari J., Brook A. and Mousavi SH. Study of cytotoxic and apoptogenic properties of Saffron extract in human cancer cell lines. Food and Chemical Toxicology. 2008, 46(11), 3443-3447. Ghazvini, K; Ghanaat, J; Tavakkol Afshari, J. and Malvandi M.Prevalence of genital Chlamydia in male patients with urethritis attending STD clinics in Northeast of  Iran. Eastern Mediterranean Health Journal, 2008, 14(6), 1333-1337. Feizzdeh B, Tavakkol Afshari J., Rakhshandeh H., Rahimi, A., Brook A. and Doosti H. Cytotoxic effect of Saffron stigma aqueous extract on human transitional cell carcinoma and mouse fibroblast. Urology Journal, 2008, 5(3): 161-167. Ghodusi J., Tavakkol Afshari J., Donyavi Z., Brook A., Disfani R. and Esmaeelzadeh M. Cytotoxic effect of new endodontic cement and mineral trioxide aggregate on L929 line culture. IEJ, 2008, 3(2), 17- 23. Shahrokhabadi K., Afshari RT., Alizade H., Afshari JT., Javadi GR. Compared two methods of isolating RNA from freezing and nonfreezing bread wheat (Tritcum aestivum L.) plant tissues. Asian Journal of Plant Sciences, 2008, 7(5): 505-509. Nassiry MR., Sadeghi B., Tohidi R., Tavakkoli Afshari J. and Khosravi M. Comparison of bovine lymphocyte antigen DRB3.2 allele frequencies between two subpopulations of Iranian Holstein cattle. African Journal of Biotechnology, 2008, 7(15), 2671-2675. Jalil Tavakkol Afshari, Hamid Reza Sima, Reza Mirzaei, Narges Valizadeh, Ahmad Ebadian, Abulfazl Mahmood Zadeh, Mohammad Khaedalouei, Houshang Rafatpanah, Ali Mokhtarifar. Influence of interleukin-10 gene promoter polymorphisms on disease progression in patients infected with hepatitis B virus. Gastroenterology, suppl. 1, 2008, 134(4): A786. Zahra Rezaieyazdi, Jalil Tavakkol-Afshari, Ehsan Esmaili, Elyas Orouji, Fakhrozaman Pezeshkpour, Mohammad Khodadoost, Maryam Mazhani, and Mahnaz Sandooghi. Association of HLA-DQB1 Allelic Sequence Variation with Susceptibility to Systemic Lupus Erythematosus. IJAAI, 2008, 7(2): 91-95. Mehrdad Radvar, Jalil Tavakkol-Afshari, Mahboobeh N. Bajestan, Mohammad-Reza Naseh, Hamid-Reza Arab. The Effect of Periodontal Treatment on IL-6 Production of Peripheral Blood Monocytes in Aggressive Periodontitis and Chronic Periodontitis Patients. IJI, 2008, 5(2), 100-106. Nemati A., Boskabady MH., Tavakkol Afshari J., Mohaghegh Hazrati S. and Haeri Rohani A. The Effect of the natural adjuvants on cell count in lung lavage of sensitized guinea pigs. Pharmacologhonline. 2008; 1:270-278. Jalil Tavakkol Afshari, Zahra Rezaieyazdi and Maryam Mazhani. Association of IL-1 beta gene polymorphism with susceptibility to systemic lupus erythematosus. Int J Rheumatic Diseases. 2008, 11:30-32. Bagherian A., Nematollahi H., Afshari JT. and Moheghi N. Compersion of allel frequency for HLA-DR and HLA-DQ between patients with ECC and caries-free children. J Indian Soc Perdod Prev Dent. 2008, 26(1): 18-22. Ghada Kchour, Mahdi Tarhini, Nourieh Sharifi, Reza Farid, Ali Reza Khooei, Abbas Shirdel, Jalil Tavakkol Afshari, Ali Sadeghian, Zaher K. Otrock, Olivier Hermine, Marwan El-Sabban and Ali Bazarbachi. Increased microvessel density in involved organs from patients with HTLV-I associated adult T cell leukemia lymphoma. Leukemia & Lymphoma, Month, 2008, 49(2): 265-270. Akbari MR., Kermanshahi H., Nassiri Moghaddam H., Heravi Moussavi AR. And Tavakkol Afshari J. Effects of wheat-soybean meal based diet supplememtation with vitamin A, vitamin E and Zinc on blood cells, organ weights and humoral immune response in Broiler chickens. Journal of Animal and Veterinary advances. 2008, 7(3): 297-304. Seilanian Toosi M., Rafatpanah H., Tavakkol Afshari J., Ghavam Nassiri MR., Sima HR., Malekzadeh Moghani M. and Ganjali R. The role of Tumor Necrosis Factor- promoter polymorphisms in gastric carcinoma in Iranians: A case-control study in the North-East of Iran. Govaresh 2007; 12(3), 192-199. Gharehbaghi MM., Maamuri GA., peirovifar A., Boskabadi H., Afshari JT., and Shakeri MT. Immediate diagnosis of early onset sepsis in premature newborns by measurement of cord C-reactive protein and interleukin-6. Iranian Journal of Medical Sciences 32(4), 217-221, 2007. Hesabi Nameghi A., Moghaddam Nassiri H., Tavakkol Afshari J. and  Kermanshahi H. Effects of Vitmain E on performance and immune response of 'Broiler Chicks. J. Agricultural Sciences & Technology Journal (Persion). 2007; 20(7):123-135. Jalil Tavakkol Afshai, Khadigeh Nejad Shahrokhabadi, Hassan Rakhshandeh and Azam Brook. Cytotoxic effect of total Saffron extract on human hepatocellular carcinoma (HCC). Clinical Immunology, Vol. 123, Suppl. 1; 2007; S110. Arab HR., Tavakkol Afshari J., Baghani Z. and Mohegi N. Quantitative evaluation of interleukin-6, interleukin-11 and intereukin-17 in healthy an dinflammatory tissues of givival. Clinical Immunology, Vol. 123, Suppl. 1; 2007; S110. Tavakkol Afshari J., Aghasizadeh N., Bidar M., Fhmidekar MA., Zarbi M. and Brook A. Evaluation of IL-1 beta secretion level of human osteoblasts and morphology of these cells adjunct to gray MTA, white MTA, Portland cement and IRM as retrofilling. Clinical Immunology, Vol. 123, Suppl. 1; 2007; S110. Nematollahy H., Tavakkol Afshari J. and Bagherian A. Association between HLADRB1*04 and HLADQB1*06 with severe early childhood caries. Clinical Immunology, Vol. 123, Suppl. 1; 2007; S110. Ganjali R., Tavakkol Afshari J. and Mazhani M. Evaluation of polymorphism of IL-1RN gene in patients with SLE. Clinical Immunology, Vol. 123, Suppl. 1; 2007; S110. Mehdi Seilanian Toosi, Jalil Tavakkol Afshari, Mohamad Reza Ghavam Nassiri, Mona Malekzadeh Moghani, Houshang Rafatpanah and Azam Brook. The role of Interleukin-1 beta gene polymorphism in gastric cancer in North-eastern Iran. Iranian Journal of Pathology, 2007, 2(2), 59-66. Arab, HR., Tavakkol Afshari, J., Radvar, M., Melati, E., Ebadian, AR. Analysis of -1082 interleukin-10 gene polymorphism in Iranian patients with generalized aggressive periodontitis. Medical Science Monitor, 2007, 13(11): CR510-514.

Nematollahy H., Tavakkol Afshari J. and Bagherian A. Association between HLADRB1*04 and HLADQB1*06 with severe early childhood caries. Journal of Mashhad Dental School, Mashhad University of Medical Sciences (MUMS), 2007, 31: 133-40 (Persian).

Bidar M., Tavakkol Afshari J., Zarabi MH. And Aghasezadeh, N. Evaluation of IL-1 beta seceretion level by human osteoblast cells aducent to white MTA, Dark MTA, Portland cement and IRM as a retrograde filling material. Journal of Mashhad Dental School, Mashhad University of Medical Sciences (MUMS), 2007, 31: 133-40 (Persian).

Hesabi  Nameghi A., Moghaddam Nassiri H., Tavakkol Afshari J. and  Kermanshahi H. Effects of Vitmain E and C supplementation on performance and immune response of 'Broiler Chicks. J. Animal and Veterinary Advances. 2007; 6(9): 1060-1096.

Rezaieyazdi Z., Tavakkol Afshari J., Sandooghi M. and Mohajer F. Tumour necrosis factor a -308 promotor polymorphism in patients with rheumatoid arthritis. Rheumatology International. 28(2), 189-191, 2007.

Kianifar HR., Talebi S,  Tavakkol Afshari  J., Esmaili M., Davachi  B. and Brouk, A. D28G mutation in congential glucose-galactose malabsorption. Archives of Iranian Medicine. 2007; 10(4): 514-518.

Mohammad Hassan Khazai, Bahram Khazai , Jalil Tavakkol Afshari, Javad Akbarzadeh, Mohammad Reza Abbaszadegan, Ladan Khazai. IL-4 and Interferon gamma in recently diagnosed type I diabetes, A case-control study. ARYA Atherosclerosis Journal.  2007 (Spring); Volume 3, Issue 1: 1-7.

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