The Pharmaceutical Research Center
Buali (Avicenna) Research Institute
Mashhad University of Medical Sciences
Pharmacodynamics Unit 
Pharmaceutical Research Center Pharmacodynamics Unit

           Dr. Hosseinzadeh, Hossein (PhD in Pharmacology)
           Dr. Moatamedolshariati, Vahide sadat (Pharm.D.)


  • Toxicological and pharmacological investigations of chemical agents and herbal medicines with emphasis on native plants such as Crocus sativus L. (Saffron) and Salvia leriifolia (Nourozak)


  • Antinociceptic effects of crocin and safranal in mice.

  • Protective effect of aqueous and ethanolic extracts of Salvia leriifolia on diminishing damages caused by renal ischemia in rats.

  • Protective effect of saffron aqueous extract and crocin, as one of the active constituent of saffron on diminishing damages caused by renal ischemia in rats.

  • Acute and subacute toxicity effects of crocin and safranal in rats

  • Antidepressant effect of N-substituted imidazole carboxamides in the forced swimming test model in mice.

  • Effects of aqueous extract of Pinus eldarica (pine fruit) in treatment or prevention of renal calcium oxalate formation.

  • Effects of Crocus sativus aqueous extract and its two constituents, crocin and safranal, in an experimental Multiple Sclerosis model in rats.

  • Protective effect of the saffron stigma in reduction of reperfusion syndrome lesions after vascular clamping of the lower limb

  • Effect of saffron aqueous extract and its two constituents, crocin and safranal, on the prevention of cataract caused by galactose in rats



Last Update : 2017-12-13 04:59:05

Mashhad University of Medical Sciences Contact Details:
Main address: University St., Ghoraishy Building 91375-345 Mashhad, Iran ,
Tel:( 98 511) 841 2081-5 , Fax:( 98 511) 8430249 , E-mail: Info(at) Members: - Schools and Hospitals School: Dentistry , School: Health , School: Medicine , School: Nursing & Midwifery , School: Paramedical , School: Pharmacy , School: Traditional Medicine , Hospital: Dr.Sheikh , Hospital: Dr.Shariati , Hospital: Emam Reza , Hospital: Ghaem , Hospital: Hashemi Nezhad , Hospital: Ibn-e-Sina , Hospital: Khatam-al-Anbia , Hospital: Montaserie , Hospital: Ommul-Banin , Hospital: Omid , Hospital: Shahid Kamyab , Hospital: Taleghani , History: Mashhad Faculty of Medicine was officially opened on Nov. 23, 1949 by Dr Zanganeh, the minister of culture. The school started out with 61 students, one associate professor and seven tutors. In 1956, when the school of Arts opened, the two schools merged to form the University of Mashhad. In 1989, the faculties offering Medical Sciences' degrees across the country separated from the Ministry of Culture and Higher Education. New emerging Medical Universities have gone under management of Ministry of Health, Treatment and Medical Education. Thus the original University of Mashhad was divided into two independent universities: "Ferdowsi University of Mashhad" and "Mashhad University of Medical Sciences'. Mashhad University of Medical Sciences operates at present with 8 faculties, 32 hospitals, 179 rural and 147 urban health centers. It covers an enormous area stretching from the north east to the central parts of the country, which makes it the largest university of Medical Sciences providing health care and treatment services. With 597 teaching staff, 1645 MDs with different specialties, 138 dentists, 123 pharmacists and 25, 402 employees, the university provides health care and medical services to the area's large population as well as to over 25 million tourists a year.

Pharmaceutical Research Center, BuAli Research Institute, BuAli Square, Mashhad -Iran, Postal Code: 9196773117, Tel.: (+98 51) 37112470, Fax:( +98 51) 37112470, Email:
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