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pharmaceutical >PolymerTecnology

The Pharmaceutical Research Center
Buali (Avicenna) Research Institute
Mashhad University of Medical Sciences
 
Polymer Technology Unit
Head:
 
Molecular imprinting

Definition and Applications

 

Molecular imprinting is a technique for preparing polymers with structure-selective adsorptive properties. This is achieved by arranging functional monomers around a template compound and then fixing the monomers in this spatial arrangement with a cross linker. An ideal molecularly imprinted polymer (MIP) has homogeneous binding sites which show no co-operative properties and no matrix effects .Such an MIP could find uses as the sorbent in SPE as the stationary phase in HPLC , and as the receptor layer in biosensors. It is probably the use of MIPs in biosensors which holds the greatest promise of enabling researchers to create analytical systems for highly selective, robust, and fast, one step assays.

 

Activities

1.    Application of molecularly imprinted solid-phase extraction (MISPE) in selective extraction of chemicals from herbal extracts, human serum and other biological fluids and tissues.

2.    Application of MIPs in preparation of novel drug delivery systems (e.g. molecularly imprinted soft contact lenses for ocular drug delivery)

3.    Preparation and investigation of molecularly imprinted micro and nano particles.

4.    Application of MIPs in water treatment and detoxification of aqueous media

 

Proposals

 

1.    Preparation of ocular drug delivery soft contact lens for brimonidine, in-vitro evaluations of its binding properties and in-vivo studies in rabbit eye.

2.    Extraction and analysis of haloperidol in rabbit tissues using its molecularly imprinted polymer.

3.    Preparation of histamine imprinted polymer, study of its binding properties and its application in extraction of histamine from canned fish.

4.    Extraction of lactose from milk by means of its polymeric receptor.

5.    Preparation of clozapine imprinted polymer, study of its binding properties and its application in drug assay in serum.

6.    Evaluation of diclofenac release from its molecularly imprinted polymer in aqueous and organic solvents.

7.    Preparation of poly (hydroxylethyl methacrylate) hydrogels as new ocular drug delivery systems and study of their binding and drug release properties.

8.    Synthesis of crocin imprinted polymer and study of its binding properties.

9.    Synthesis of omeprazole and pantoprazole imprinted polymers and study of their binding characteristics in aqueous and organic solvents.

10.   Extraction and analysis of diazinon in cucumber using its molecularly imprinted polymer.

11.   Extraction and analysis of haloperidol in rabbit tissues using its molecularly imprinted polymer.

12.   Synthesis of molecularly imprinted nanoparticles for some organophosphates (Glyphosate, Malathion, Dichlorvos) and their binding properties in organic and aqueous media.

13.  Preparation of molecularly imprinted nanoparticles in precipitation using microwave and classic methods and study of their binding properties

 

Publications:

 

1.    Clozapine imprinted polymers: synthesis, characterization and application for drug assay in human serum

2.    Extraction of crocin from saffron (Crocus sativus) using molecularly imprinted polymer solid-phase extraction

3.    Clozapine Recognition via Molecularly Imprinted Polymers; Bulk Polymerization Versus Precipitation Method

4.    Development of a pH-responsive imprinted polymer for diclofenac and study of its binding properties in organic and aqueous media

5.    Controlled release of prednisolone acetate from molecularly imprinted hydrogel contact lenses.

6.    Application of molecularly imprinted hydrogel for the preparation of lactose-free milk.

7.    Non-covalently lactose imprinted polymers and recognition of saccharides in aqueous solutions.

 

Last Update : 2017-12-13 04:57:22

Mashhad University of Medical Sciences Contact Details:
Main address: University St., Ghoraishy Building 91375-345 Mashhad, Iran ,
Tel:( 98 511) 841 2081-5 , Fax:( 98 511) 8430249 , E-mail: Info(at)mums.ac.ir Members: - Schools and Hospitals School: Dentistry , School: Health , School: Medicine , School: Nursing & Midwifery , School: Paramedical , School: Pharmacy , School: Traditional Medicine , Hospital: Dr.Sheikh , Hospital: Dr.Shariati , Hospital: Emam Reza , Hospital: Ghaem , Hospital: Hashemi Nezhad , Hospital: Ibn-e-Sina , Hospital: Khatam-al-Anbia , Hospital: Montaserie , Hospital: Ommul-Banin , Hospital: Omid , Hospital: Shahid Kamyab , Hospital: Taleghani , History: Mashhad Faculty of Medicine was officially opened on Nov. 23, 1949 by Dr Zanganeh, the minister of culture. The school started out with 61 students, one associate professor and seven tutors. In 1956, when the school of Arts opened, the two schools merged to form the University of Mashhad. In 1989, the faculties offering Medical Sciences' degrees across the country separated from the Ministry of Culture and Higher Education. New emerging Medical Universities have gone under management of Ministry of Health, Treatment and Medical Education. Thus the original University of Mashhad was divided into two independent universities: "Ferdowsi University of Mashhad" and "Mashhad University of Medical Sciences'. Mashhad University of Medical Sciences operates at present with 8 faculties, 32 hospitals, 179 rural and 147 urban health centers. It covers an enormous area stretching from the north east to the central parts of the country, which makes it the largest university of Medical Sciences providing health care and treatment services. With 597 teaching staff, 1645 MDs with different specialties, 138 dentists, 123 pharmacists and 25, 402 employees, the university provides health care and medical services to the area's large population as well as to over 25 million tourists a year.

Pharmaceutical Research Center, BuAli Research Institute, BuAli Square, Mashhad -Iran, Postal Code: 9196773117, Tel.: (+98 51) 37112470, Fax:( +98 51) 37112470, Email: PRC@mums.ac.ir
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