Topical Effect of Kiwifruit versus Elase Ointment on Removal of Necrotic Tissue of Full-thickness Burns in Male Rats
Hadi Koshiar1, Hadi Abbaspour2, Hasan Rakhshandeh3, Abolfazl Khajavi4
1- Instructor of Nursing, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Iran
2- MSc of Nursing
3- Instructor of Pharmacology, School of Medicine, Mashhad University of Medical Sciences, Iran
4- Assistant Professor of Physiology, School of Medicine, Mashhad University of Medical Sciences, Iran
Background and Objective: The presence of necrotic tissue is an important problem in patients with deep burns. To remove these tissues surgical procedures are usually used which are problematic and with limited indications. This study was designed to compare topical effectiveness of kiwifruit versus Elase ointment on removal of necrotic tissue of full-thickness burns.
Materials and methods: Thisexperimental study was accomplished on 10 Vistar rats that assigned to three groups. Full thickness burns with 3cm diameter were produced in all rats. One side of the first group was treated by Elase ointment and the other side by topical kiwifruit. In second group one side was treated by Elase ointment or topical kiwifruit and the other side was considered as control group 2. All wounds in group three were considered as control group 1. In each group the time of removing necrotic tissues, the instant of infection occurrence and forming granulate tissue were recorded in a check list and then were analyzed using non-parametric statistics.
Results: Findings showed that debridement time of kiwifruit (5.7days) was significantly shorter than Elase ointment group (18.5 days) (p<0.029). Surprisingly in the kiwifruit groups no infection was observed.
Conclusion: Using kiwifruit not only causes no injury to healthy tissues but also resulted in shorter debridement time. Findings of this study can open new horizons and provide a new treatment modality for patients with deep burns.
Keywords: Burns, Necrosis, Debridement, Actinidin, Elase, Ointments
J Mashhad School Nurs Midw 2009; 9 (1): 7-12