Results from eleven independent ALS (Lou Gehrig's Disease) research studies are giving hope to the ALS community - showing for the first time that the disease may be treatable by targeting new mechanisms revealed by neural stem cell-based studies. A decade of research conducted at multiple institutions, shows that when neural stem cells were transplanted into multi-levels of the spinal cord of a mouse model with familial ALS, disease onset and progression slowed, motor and breathing function improved and treated mice survived three to four times longer than untreated mice. A summary of the findings from all eleven studies published online December 19 in Science Translational Medicine.
"This significant research will help us better understand the mechanisms underlying motor neuron diseases," said Yang (Ted) Teng, PhD, MD, the study's co-lead author and director of the Spinal Cord Injury and Stem Cell Biology Research Laboratory in the Department of Neurosurgery at Brigham and Women's Hospital. "This work sheds new light on detrimental roles played by non-neuronal cells in triggering motor neuron death and these events should be targeted for developing more effective therapeutics to treat ALS."
Stem Cell Research Shows ALS May Be Treatable
Last Update : 2017-12-13 04:38:20