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دكتر محمدرضا عباس زادگان
(PhD ژنتیک انسانی)
دانشیار گروه ایمونولوژی
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آدرس: مشهد ، میدان بوعلی ، پژوهشکده بوعلی ، مرکز تحقیقات ایمونولوژی ، بخش ژنتیک انسانی
تلفن: 5-05117112611 - 05117112343
نمابر: 05117112596 |
CERTIFICATION
Medical Geneticist: American Board of Medical Genetics (FABMG)
Clinical Molecular Geneticist, National Human Genome Research Institute, NIH
Medical Technologist: American Society of Clinical Pathologist (ASCP)
Medical Laboratory Scientist: National Certifying Agency (NCA)
EDUCATION
7/03- 10/03 Fellowship –Diagnosis of Rare Genetic Diseases & their Prenatal Genetic Diagnosis, GeneDx, Inc. DNA Diagnostic
Institute affiliated with NIH, Director: Sherri Bale, Ph.D., FABCG.
1/98- 1/2000 Fellowship – Clinical Molecular Genetics, The American Board of Medical Genetics
NIH/ Georgetown / Children’s Medical Center Joint fellowship program
Program Director: Clair A. Francomano, M.D.
6/95- 11/97 Postdoctoral Fellow-Intramural Research Training Award (IRTA)
Diagnostic Development Branch
National Human Genome Research Institute, NIH, Bethesda, Maryland 20892
Advisor: Mark R. Hughes, M.D., Ph.D.
Project: Research and Development of new diagnostic assays for human genetic
diseases, Prenatal genetic diagnosis & Familial Breast Cancer
8/90-5/95 Ph.D. in Pharmacology & Toxicology
University of Arizona Medical Center, Tucson, Arizona 85721
Minor: Microbiology & Immunology
Major Advisor: William S. Dalton, M.D., Ph.D.
Dissertation: Molecular Mechanisms of Drug Resistance in Human Malegnancies.
1/87-12/90 Master of Science in Applied Microbiology
Northern Arizona University, Flagstaff, Arizona 86011
Major Advisor: Emmanuel T. Akporiaye, Ph.D.
Thesis: Tumoricidal Activity of Tumor Infiltrating T-lymphocytes Against EMT6 (mammary carcinoma) Tumor Cells,
Following the Injection of Viable or Irradiated Tumor Cells.
7/85-8/86 Medical Technology Internship Program
Bannock Regional Medical Center, Pocatello, Idaho 83204
Certificates: American Society of Clinical Pathologist (ASCP) & National Certifying Agency (NCA)
9/81-6/85 Bachelor of Science in Microbiology
University of Montana, Missoula, Montana 59801
TEACHING EXPERIENCES
8/00-present Instructor, Medical Genetics, Mashhad University of Medical Sciences (MUMS)
8/00-present Instructor, Molecular Biology, Graduate students, MUMS
1/98-5/98 Instructor, Molecular Genetics, Georgetown University Medical Center
5/96-8/96 Summer Student Training, National Center for Human Genome Research, NIH
8/87-5/89 Laboratory Instructor, Department of Biological Sciences, Northern Arizona
University, Flagstaff, Arizona 86011
Fall 1989 Immunobiology and General Biology
Spring 1989 Advanced Immunology and General Biology
Fall 1988 Immunobiology
Spring 1988 Bacteriology
Fall 1987 Immunobiology
RELEVANT WORK EXPERIENCE
11/96- 8/98 Assistant Professor
Institute for Molecular & Human Genetics
Georgetown University Medical Center
3800 Reservoir Road, 4 Main, M4000
Washingtion D.C. 20007
Research projects :
1. Development of new strategies & new techniques to improve the genetic testing of Cancer predisposition genes in high risk families.
2. Study of mechanisms of tumor porgression in the individuals with a alteration in the breast and ovarian cancer susceptibility genes,
BRCA1 and BRCA2.
6/95- 11/96 Postdoctoral Fellow
Diagnostic Development Branch
National Center for Human Genome Research, NIH, Bethesda, Maryland 20892
Principal investigator: Mark R. Hughes, M.D., Ph.D.
Project: Research and Development of new diagnostic assays for human
genetic diseases, Prenatal & Preimplantation genetic diagnosis & Familial
Breast Cancer
1/90-8/90 Research Assistant II
University of Arizona Medical Center, Tucson, Arizona 85721
Internal Medicine/Gastroenterology
Principal investigator: David Earnest, M.D.
Project: Studying the mechanism of vitamin A potentiation of xenobiotic hepatotoxicity; vitamin A activation of
Kupffer cells in vitro and in vivo.
8/87-12/89 Teaching Assistant
Northern Arizona University, Flagstaff, Arizona 86011
Department of Biological Sciences
6/88-3/89 Medical Technologist
Public Health Service Indian Hospital, Tuba City, Arizona 86045 Laboratory Services
Laboratory Manager: Bruce Gardner
6/87-8/87 Research Assistant
Dept. of Biological Sciences, Northern Arizona University, Flagstaff, Arizona 86011
Principal Investigator: Emmanual T. Akporiaye, Ph.D.
Project: Tumor Immunology
AWARDS
6/1988 Sigma Xi, The Scientific Research Society
6/1995 National Institute of Health Intramural Research Training Award (IRTA)
3/1996 NIH Fellows Award for Research Excellence
12/2005 Khwarizmi First Award for Applied Medical Protocols (Congenital Adrenal Hyperplasia)
PROFESSIONAL SOCIETIES
The Academy of Medical Sciences, I.R. of IRAN
American Society of Human Genetics
American Association for the Advancement of Science
Associate Member, American Association for Cancer Research
Student/Fellow Member, American Society for Microbiology
American Society of Medical Technologists
GRANTS & Licensing A Technology
Primary Investigator:
6/97-7/99 Department of Defense, Army Breast Cancer Grant - A case controlled study of somatic changes in primary
breast tumors from BRCA1 & BRCA2 mutation carriers compared to sporadic breast tumors. $161,000 annual for 3 years.
5/97-7/98 Transfer of technology “5’ Nuclease Allelic Discrimination Assay” - License Agreement between Institute
for Molecular & Human Genetics, Georgetown University Medical Center and Institute of Medical Molecular Genetics, Berlin, Germany. $ 22,500 in Direct cost.
Co-Investigator:
10/96-10/98 National Institute of Health, Screening for mutations in Breast and Ovarian Cancer Susceptibility Genes,
BRCA1 and BRCA2, in high risk families and psyco-social behavioral aspects of this genetic testing (C. Lerman, P.I.).
6/97-7/99 Department of Defense, Army Breast Cancer Grant - Study of chromosomal imbalances in microdissected
breast tumor cells from a heterogenous population of cells derived from a breast tumor section (B. Haddad, P.I.).
Research Projects in Iran
Division of Human Genetic, Immunology Research Center, MUMS
Cancer Genetics:
1. Evaluation of exfoliative cytology and new serum biomarkers in screening of esophageal squamous cell carcinoma
(Approved by national medical research council).
2. Evaluation of GST1 polymorphisms as biomarkrs in screening of Esophageal Carcinoma.
3. Evaluation of Long DNA and BAT-26 Markers in detection of colorectal cancer by molecular analysis of patient's stool
DNA in comparison with normal subjects.
4. Evaluation of frequency of changes in P14 & P16 genes in CRC patients.
5. Prognostic Significance of Germ-line E-Cadherin Mutation in Familial Gastric Cancer.
6. Molecular analysis of Wnt signaling pathway in Gastric cancer
7. Microsatellite analysis in colorectal cancer patients.
8. Analysis and comparison of gene expression in hepatocellular carcinoma with a normal cell line following the treatment
of HESA-2 by cDNA Microarray technology.
9. Study of the association of HPV infection and P53 mutation with esophageal SCC.
10. Microsatellite markers analysis in endometrial & ovarian cancer.
11. Assessment of P53 mutation in pathological staging and surgical margins in squamous cell carcinoma of the head and neck.
Medical Genetics:
1. Molecular Analysis of CYP-21 gene in 21-hydroxylase deficiency in congenital adrenal hyperplasia patients in Iran.
2. Friedreich Ataxia: Molecular detection of FRDA GAA repeats in proband from a family in province of Khorasan.
3. Preimplantation Genetics Diagnosis of b- thalassemia using single cell PCR techniques.
4. Carrier detection and Prenatal diagnosis of Hemophilia A and Finding of their Common mutation by Molecular Genetics
in Khorasan province
5. Mutation Detection of TCIRG1 Gene in patients with osteopetrosis by PCR & RT-PCR.
6.Evaluation of HTLV-I tax polymorphism as a probable risk factor for HAM/TSP in Khorasanian patients.
Biotechnology:
1. Designing, production and evalution of HTLVI, II diagnostic kit for detection of antibody against HTLV virus using
HTLV recombinant Envelope proteins.
Funded by National Medical Biotechnology Network
PUBLICATIONS
Articles
Abbaszadegan MR, Tavasoli A, Velayati A, Sima HR, Vosooghinia H, Farzadnia M, Asadzedeh H, Gholamin M,
Dadkhah E: Stool-based DNA Testing, A New Noninvasive Method for Colorectal Cancer Screening, The First Report from Iran.
World J. Gastroentrology, 13(10): 1528-1533, 2007.
Abbaszadegan MR, Tavasoli A, Velayati A, Dadkhah E: Rapid DNA extraction protocol from stool, suitable for
molecular genetic diagnosis of colon cancer. Iranian Biomedical J. Accepted 2007.
Kamalidehghan B, Houshmand M, Shafa Shariat Panahi M, Ismail P, Amri Saroukolaei S, Banoei MM,
Abbaszadegan MR: TheY8.9 kb Deletion in Tumoral Cell mtDNA Is More Common than Other Deletions in Gastric Cancer.
Archives of Medical Research. Mar 2006.
Mostaan L.Abbaszadegan MR., Ghafarzadegan K., Seyyedi M, Arabi A, Salehi M, Afzalaghaei: Evalation of E-cadherin
and its correlation with lymphatic metastasis and tumor grade in laryngeal SCC. The Iranian J. Otorhinolaryngology. Vol. 18. No.44, 2006
Kahrom M,Abbaszadegan MR, Kahrom H, Vakili R: Nager's acrofacial dysostosis with hypertrophic cardiomyopathy:
Report of a case. Saudi Medical Journal, in press, 2006.
Abbaszadegan MR, Raziee HR, Ghaffarzadegan K, Shakeri MT, Afsharnejad S, Ghavamnasiri MR S: Aberrant p16
methylation, a possible epigenetic risk factor in familial esophageal squamous cell carcinoma.
Int. J. Gastrointestinal cancer, 36:426-430, 2005.
Vakili R, Baradaran Heravi A, Barid Fatehi B, Gholamin M, Ghaemi N,Abbaszadegan MR: Molecular Analysis
of the CYP21 Gene and Prenatal Diagnosis in Families with 21- Hydroxylase Deficency in Northeasterm Iran.
Hormone Research, 65: 119-124, 2005
Rafatpanah H, Pravica V, Farid R, Abbaszadegan MR, Tabatabaei A, GohariooA, Etemadi MM, Hutchinson Ian
V: Association of a Novel Single Nucleotide Polymorphism in the Human Perforin Gene With the Outcome of HTLV-I
Infection in Patients From Northeast Iran (Mashhad). Human Immunology, 65, 839-846, 2004.
Ghaffarzadegan K, Zali MR, Jami Ahmadi Kh, Asadzadeh HR, Abbaszadegan MR: Correlation of Nuclear p53
Immunoreaction with the Histopathologic Features in Gastric Carcinoma. Archives of Iranian Medicine, 7(4): 279-283, 2004.
Abbaszadegan MR, Ghavamnasiri MR, Raziee HR, Ghaffarzadegan K, Afsharnejad S. P16/ INK4a promoter
hypermethylation in serum, blood and tumor of patients with esophagel squamous cell carcinoma.
Iranian J. Basic Medical Sciences, 4(6):, 2004.
Abbaszadegan MR, Omidi A, Niyazi A, Zoheidi MR, Gholamin M, Jami-Ahmadi K, Ghaffarzadegan K. Prevalence of
Human Papilloma Virus type 16 and 18 and expression of mutant p53 in Esophageal Squamous Cell Carcinoma.
Iranian J. Basic Medical Sciences, 4(6): 38-42, 2004
Abbaszadegan MR, Gholamin M, Tabatabaee A, Farid R., Houshmand M., Abbaszadegan M. Prevalence of Human
T-Lymphotropic Virus Type 1 among blood donors from Mashhad, Iran. J. Clin. Microbio. 41(6): 2593-2595, 2003.
Abbaszadegan MR, Pazouki N, Sankian M: DNA extraction from Mutation Detection Enhancement (MDE)
gel stained with silver nitrate. Protocol Online, 2003.
Yazdani A, Chung Do D, Abbaszadegan MR, Khayer KA, Chan WM, Yazdani M, Ghodsi K, Engele E, Traboulsi E:
A novel PHOX2A/ARIX mutation in an Iranian family with Congenital Fibrosis of Extraocular Muscles type 2-CFEOM2.
The American Journal of Ophthalmology,5(136): 861865, 2003.
Ashrafzade F, Abbaszadegan MR, Ghaemi N: Fragile X Syndrome A case report with fingers anomaly.
HamedanUniversityMed. Science J 16(2): 132-134, 2003
Gelmann EP, Steadman DJ, Ma J, Ahronovitz N, Voeller JH,Swope S,Abbaszadegan MR, Brown KM,
Strand K, Hayes RB, Stampfer MJ: Occurrence of NKX3.1 C154T polymorphism M. R. in men with and
without prostate cancer and studies of its effect on protein function. Cancer Res. 62(9): 2654-9, 2002.
Farid-Hosseini F, Pishnamaz R, Farid-Hosseini R, Abbaszadegan MR, Mahmoodi M, Rasteen M:
Expression of Interleukin-2Ra chain (CD25) on peripheral blood lymphocytes in HTLV-I associated
myelopathy/Tropical Spastic Paraparesis patients. Arch Irn Med 4(4): 183-187, 2001.
Abbaszadegan MR, Shirdel A, Soroori J, Gholami B, Gholamin : Detection of minimal residual disease in
CML patients after bone marrow transplantation using a semi-quantitative RT-PCR of BCR-ABL fusion gene
(Persian). Iranian J. Basic Medical Sciences, 4(4):183-187, 2001.
SchmidtF, Abbaszadegan MR, Hauser A; Buwitt U; Laut P otschick K; Krocker J; Elling D; Grosse R:
Detection of BRCA1 and BRCA2 mutations in breast cancer families by a comprehensive two-stage screening
procedure. Int J Cancer, 85(4): 474-81, 2000.
Lerman C, Hughes Ch; Bruce J; Main D;Bonney A; Abbaszadegan MR; Myers R; Harty A; Franklin B; Lynch J; Lynch H:
Genetic Testing in Families With Hereditary Nonpolyposis Colon Cancer. JAMA. 1999; 281(17): 1618 – 1622.
Abbaszadegan MR, Varasteh AR, Khoshroo M, Gholami B, Gholamin M. Isolation and purification of TAX protein
of HTLV-1 virus using recombinant DNA Techniques. I.R. Iran Biotechnology 3: 456-461, 1999.
Abbaszadegan MR, Streuwing J, Brown KM, Jim Snider, Gore-Langton R, Hughes MR: Automated detection of
highly prevalent mutations in BRCA 1 and 2 genes using a fluorogenic PCR. Genetic Testing 1: 171-180, 1998.
Abbaszadegan MR, Cress AE, Futscher BW, Bellamy WT, Dalton WS: Evidence for cytoplasmic P‑glycoprotein
location associated with increased multidrug resistance and resistance to chemosensitizers. Cancer Res. 56: 5435-5442, 1996.
Abbaszadegan MR, Foley NE, Guzman MC, Dalton WS: Resistance to The Chemosensitizer, Verapamil, in a
Multidrug Resistant (MDR) Human Multiple Myeloma cell line. Int. J. Cancer 66: 506-514, 1996.
Abbaszadegan MR, Futscher BW, Klimecki WT, List A, Dalton WS: Analysis of Multidrug Resistance-associated
Protein (MRP) mRNA in normal and malignant hematopoietic cells. Cancer Res. 54: 4676-4679, 1994.
Futscher BW,Abbaszadegan MR, Domann F, Dalton WS: Analysis of MRP mRNA in Mitoxantrone-selected,
multidrug resistant human tumor cells. Biochem. Pharmacol. 47: 1601-1606, 1994.
Abril ER, Scuderi P,Abbaszadegan MR, Watzl B, Earnest DL: Vitamin A indirectly activates kupffer cells by
stimulating cytokine production by peripheral blood mononuclear leukocytes. Cells Hep. Sinusoid 3: 27-29, 1991.
Watzl B, Abril ER,Abbaszadegan MR, Scuderi P, Watson RR: Effects of ethanol in vivo on TNF secretion by
cultured rat kupffer cells. Cells Hep. Sinusoid 3: 480-482, 1991.
Abstracts & invited scientific Presentations :
Abbaszadegan MR.Molecular genetics and epigenetics in upper GI cancers. The first Esophageal Cardia Cancer
Summit, Scientific sponsors: ISMO, DDRC, IAGH, Iran & IARC, France, Tehran, Iran, Dec. 13-14, 2005.
Abbaszadegan MR. Genetics of Colorectal Cancer. The 5th Iranian Congress of Gastroenterology and Hepatology,
Tehran, Iran, Dec. 14-18, 2005.
Velayati A, Sima HR, Vosooghinia H, Abbaszadegan MR, Dadkhah E, Tavasoli A. Stool-based DNA testing,
new non-invasive method of colorectal cancer screening, first report from Iran. The 5th Iranian Congress
of Gastroenterology and Hepatology, Tehran, Iran, Dec. 14-18, 2005.
Abbaszadegan MR, Raziee HR, Afsharnejad S, Ghaffarzadegan K, Ghavamnasiri MR. Aberrant p16 Methylation,
a possible predisposing factor in familial Esophageal squamous cell carcinoma. 95th Annual meeting of American
Association for Cancer Research, Orlando, Fl, March 2004.
Abbaszadegan MR, Heidari N, Pazuki N, Jami-Ahamadi K: Mitochondria DNA Alteration in Gastric Cancer.
The Fتاريخ بروز رساني : سه شنبه 26/09/87 ساعت 08:57
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