2003-Present       Assistant professor of Immunology

· Dept of Immunology, Ghaem Hospital, Mash-had University of Medical Sciences, Mash-had-Iran.

·  Teaching Immunology to undergraduate and postgraduate students.

· I supervised three Master students, and two fellowship theses. In each case this involved assisting in project management, development and completion.

· I was awarded three grants from the chancellor of research, Mash-had University of Medical Sciences. The aim of these projects was to understand the role of Immunogenetic factors in human T lymphotropic virus type I (HTLV-I) and hepatitis B virus.

· Several publications resulted from these work.

· Head of HTLV-I Research lab,

Ghaem Hospital, Mash-had University of Medical Sciences.

1994-1998            Lecturer of Immunology

· Dept of Immunology, Ghaem Hospital Mash-had university of Medical Sciences, Mash-had, Iran.

· Teaching Immunology to undergraduate students.

·  I supervised six BSc. students with their final year projects, and two Master students. I directed the projects of six BSc. students and jointly supervised three Master students.

·  Head of Immunology lab

                                   Ghaem Hospital, Mash-had University of Medical Sciences, Mash-had, Iran.

1987-1992             Teaching assistant

· Dept of Immunology, Ghaem Hospital, Mash-had University of Medical Sciences, Mashhad-Iran.

 

Research Abstract  

 · Human T lymphotropic virus type (HTLV-I) is associated with HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T-cell leukaemia (ATL). Fewer than 2% of HTLV-I-infected individuals develop HAM/TSP. The different outcome of HTLV-I infection may be explained by the existence of viral agents, genetic background or even environmental factors. My research aim was to study the correlation between n cytokine gene polymorphisms, mainly Th1 and Th2, in Iranian patients with HAM/TSP, asymptomatic HTLV-I carriers and healthy controls. We also analysed the influence of HLA class II, RB1 alleles and class I HLA-A2, A30, Cw8 and B54 alleles in all three groups. I screened the promoter and first intron of the perforin gene, as a key factor in elimination of viral-infected cells, to determine novel polymorphisms. A novel polymorphism at position +418 relative to the transcription start site was detected. My research output from my PhD studies are summarized in the publication section (please see below).

I mainly investigated the role of cytokines gene polymorphism, HLA and pefrorin in HTLV-I infection individuals. My PhD research involved the following laboratory techniques: flow cytometry/immuno-fluorescent staining, cell culture, cell sorting using micro-beads, PCR, SSCP, RT-PCR, cDNS synthesis and sequencing, SNP genotyping techniques, SDS-page and agarose gel electrophoresis, western blotting, and the use of radioactive isotopes (gamma radiation), DNA cloning, cell line transfection, protein assay and gel shift assay.

Extra Curricular

 Activities

· I have knowledge of all Microsoft office programs and whilst at Manchester university attended advanced courses in Excel, PowerPoint and Word. I have a good knowledge in Bioinformatics and experienced in the use of different web sites in this field. I am familiar in a range of statistic software packages including SPSS and STATA.

 

Publication and

Presentations

· Rafatpanah H, Pravica V, Farid R, Tabatabaei A, Ollier A, Poulton K, Thomson W, Hutchnison IV.  Association between 

  HLA-DRB*1 and HLA-Cw*08 and outcome following HTTLV-I infection (submitted to International Journal of Immunogenetics).

· Rafatpanah H, Pravica V, Farid R, Abbaszadegan MR, Tabatabaei A, Goharjoo A, Hutchinson IV.

  Association of IL-10 gene polymorphisms and HTLV-I infection in northeast Iran (Mash-had) (submitted).

                                         · Reza Farid, Ramin Ghasemi, Mahmood Baradaran-Rahimi, Farahzad Jabbari, Javad Ghaffari, and Houshang Rafatpanah.

                                 Evaluation of Six Years Allergen Immunotherapy in Allergic Rhinitis and Allergic Asthma. IJAAI, 2006; 5: 29-31.

· Faridhosseni R.., Ghaffari J., Rafatpanah H., Jabbary F., Taghavi M., Shakery M.T., Thyroid Auto antibodies in Chronic Urticaria.Medical Journal of MUMS, 2006; 48:373-378 (Persian).

· Farid R, Ghafari J, Parizadeh M, Miri S, Rafatpanah H.  Prevalence of HTLV-I infection in Neishabour-Iran.

  Medical Journal of MUMS 2005; 47:417-424 (Persian).

· Rafatpanah H, Pravica V, Farid R, Abbaszadegan MR, Tabatabaei A, Goharjoo A, Etemadi MM, Hutchinson IV.

  Association of a novel single nucleotide polymorphism in the human perforin gene with the outcome of HTLV-I infection in

  patients from northeast Iran (Mash-had). Hum Immunol 2004; 65:839-46.

· Rafatpanah H, Bennett E, Pravica V, McCoy MJ, David TJ, Hutchinson IV, Arkwright PD. Association between novel

  GM-CSF gene polymorphisms and the frequency and severity of atopic dermatitis. J Allergy Clin Immunol 2003; 112:593-8.

· Farid R, Etemadi A, Rafatpanah H. Immune response in drug resistant patients with tuberculosis. Medical Journal of MUMS

  1994; 45:23-6 (Persian).

· R. Farid ,  Shirdel , M. Etemadi , H. Rafatpanah, H. Baradaran , F. Farid, B. Nikbin Phylogenetic of Human T-cell

  Lymphotropic Virus Type I in Iranians Born in Mashhad. AIM 1999; 2:20-24.

· Rafatpanah H, Jafari M, Farid R, Baradaran H. HLA typing in patients with insulin dependent diabetes type I.

  Medical Journal of MUMS 1999; 81:54-57 (Persian).

· Poster presentation; Cytokine gene polymorphism in patients with HTLV-I associated myelopathy tropical spastic paraparesis.

  BSI, December 2000, Harrogate, U.K.

· Poster presentation: Association of HLA-DR and risk of HAM/TSP in HTLV-I infected individuals. 10^th International

  Conference of HTLV-I, July 2001, Dublin, Ireland.

· Poster presentation: Novel polymorphisms in GM-CSF. December 2001, BSI, Harrogate, U.K.

· Oral presentation: Is there association between GM-CSF gene polymorphism and phenotypic variation in GM-CSF production.

  5^th Iranian Congress of Allergy and Immunology, May 2004, Mash-had, Iran.

· Poster presentation: Association of a novel single nucleotide polymorphism in the human perforin gene with the outcome

 of HTLV-I infection in patients from northeast Iran (Mash-had).  12^th International Congress of Immunology and 4^th

 Annual Conference of FOCIS. July 2004, Montreal, Canada.

Membership

 in Societies

· Iranian Society of Allergy and Immunology

· British Society of Immunology (BSI)

 

 

تاريخ بروز رساني : يكشنبه 15/10/87 ساعت 10:44