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  دكتر هوشنگ رفعت پناه (MD, PhD ایمونولوژی)
   عضو هیئت علمی گروه ایمونولوژی                                                     
  
 
 
        rafatpanahH@mums.ac.ir
hrafatpanah@hotmail.com

 
آدرس: مشهد، میدان بوعلی، پژوهشکده بوعلی، مرکز تحقیقات ایمونولوژی، بخش ایمونوژنتیک و کشت سلولی
تلفن: 5-05117112611 و  05118012762
نمابر: 
 05117112596

 

Education

1999-2003                PhD in Immunology

·Department of Immunology, The University of Manchester

·Title: Immunogenetic analysis of patients with HTLV-I (human T lyphotropic virus type I) infection: associations with HLA, cytokine and Perforin gene polymorphisms

·Project: Investigation the hypothesis that genetic factors may account for the differences in the outcome of HTLV-I infection, namely HTLV-I carrier status or HTLV-associated myelopathy/tropical spastic paralysis (HAM/TS). 

1992-1994                MSc in Immunology

·Dept of Immunology, Mash-had University of Medical Sciences, Mash- had, Iran

·Dissertation project: Association between HLA-DR and insulin dependent diabetes type

1983-1987                BSc. in laboratory sciences

Iran University of Medical Sciences, Tehran, Iran.
 
 

Research Experience

2003-Present       Assistant professor of Immunology

· Dept of Immunology, Ghaem Hospital, Mash-had University of Medical Sciences, Mash-had-Iran.

·  Teaching Immunology to undergraduate and postgraduate students.

· I supervised three Master students, and two fellowship theses. In each case this involved assisting in project management, development and completion.

· I was awarded three grants from the chancellor of research, Mash-had University of Medical Sciences. The aim of these projects was to understand the role of Immunogenetic factors in human T lymphotropic virus type I (HTLV-I) and hepatitis B virus.

· Several publications resulted from these work.

· Head of HTLV-I Research lab,

Ghaem Hospital, Mash-had University of Medical Sciences.

1994-1998            Lecturer of Immunology

· Dept of Immunology, Ghaem Hospital Mash-had university of Medical Sciences, Mash-had, Iran.

· Teaching Immunology to undergraduate students.

·  I supervised six BSc. students with their final year projects, and two Master students. I directed the projects of six BSc. students and jointly supervised three Master students.

·  Head of Immunology lab

                                   Ghaem Hospital, Mash-had University of Medical Sciences, Mash-had, Iran.

1987-1992             Teaching assistant

· Dept of Immunology, Ghaem Hospital, Mash-had University of Medical Sciences, Mashhad-Iran.

 

Research Abstract  

 · Human T lymphotropic virus type (HTLV-I) is associated with HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T-cell leukaemia (ATL). Fewer than 2% of HTLV-I-infected individuals develop HAM/TSP. The different outcome of HTLV-I infection may be explained by the existence of viral agents, genetic background or even environmental factors. My research aim was to study the correlation between n cytokine gene polymorphisms, mainly Th1 and Th2, in Iranian patients with HAM/TSP, asymptomatic HTLV-I carriers and healthy controls. We also analysed the influence of HLA class II, RB1 alleles and class I HLA-A2, A30, Cw8 and B54 alleles in all three groups. I screened the promoter and first intron of the perforin gene, as a key factor in elimination of viral-infected cells, to determine novel polymorphisms. A novel polymorphism at position +418 relative to the transcription start site was detected. My research output from my PhD studies are summarized in the publication section (please see below).

I mainly investigated the role of cytokines gene polymorphism, HLA and pefrorin in HTLV-I infection individuals. My PhD research involved the following laboratory techniques: flow cytometry/immuno-fluorescent staining, cell culture, cell sorting using micro-beads, PCR, SSCP, RT-PCR, cDNS synthesis and sequencing, SNP genotyping techniques, SDS-page and agarose gel electrophoresis, western blotting, and the use of radioactive isotopes (gamma radiation), DNA cloning, cell line transfection, protein assay and gel shift assay.

Extra Curricular

 Activities

· I have knowledge of all Microsoft office programs and whilst at Manchester university attended advanced courses in Excel, PowerPoint and Word. I have a good knowledge in Bioinformatics and experienced in the use of different web sites in this field. I am familiar in a range of statistic software packages including SPSS and STATA.

 

Publication and

Presentations

· Rafatpanah H, Pravica V, Farid R, Tabatabaei A, Ollier A, Poulton K, Thomson W, Hutchnison IV.  Association between 

  HLA-DRB*1 and HLA-Cw*08 and outcome following HTTLV-I infection (submitted to International Journal of Immunogenetics).

· Rafatpanah H, Pravica V, Farid R, Abbaszadegan MR, Tabatabaei A, Goharjoo A, Hutchinson IV.

  Association of IL-10 gene polymorphisms and HTLV-I infection in northeast Iran (Mash-had) (submitted).

                                         · Reza Farid, Ramin Ghasemi, Mahmood Baradaran-Rahimi, Farahzad Jabbari, Javad Ghaffari, and Houshang Rafatpanah.

                                 Evaluation of Six Years Allergen Immunotherapy in Allergic Rhinitis and Allergic Asthma. IJAAI, 2006; 5: 29-31.

· Faridhosseni R.., Ghaffari J., Rafatpanah H., Jabbary F., Taghavi M., Shakery M.T., Thyroid Auto antibodies in Chronic Urticaria.Medical Journal of MUMS, 2006; 48:373-378 (Persian).

· Farid R, Ghafari J, Parizadeh M, Miri S, Rafatpanah H.  Prevalence of HTLV-I infection in Neishabour-Iran.

  Medical Journal of MUMS 2005; 47:417-424 (Persian).

· Rafatpanah H, Pravica V, Farid R, Abbaszadegan MR, Tabatabaei A, Goharjoo A, Etemadi MM, Hutchinson IV.

  Association of a novel single nucleotide polymorphism in the human perforin gene with the outcome of HTLV-I infection in

  patients from northeast Iran (Mash-had). Hum Immunol 2004; 65:839-46.

· Rafatpanah H, Bennett E, Pravica V, McCoy MJ, David TJ, Hutchinson IV, Arkwright PD. Association between novel

  GM-CSF gene polymorphisms and the frequency and severity of atopic dermatitis. J Allergy Clin Immunol 2003; 112:593-8.

· Farid R, Etemadi A, Rafatpanah H. Immune response in drug resistant patients with tuberculosis. Medical Journal of MUMS

  1994; 45:23-6 (Persian).

· R. Farid ,  Shirdel , M. Etemadi , H. Rafatpanah, H. Baradaran , F. Farid, B. Nikbin Phylogenetic of Human T-cell

  Lymphotropic Virus Type I in Iranians Born in Mashhad. AIM 1999; 2:20-24.

· Rafatpanah H, Jafari M, Farid R, Baradaran H. HLA typing in patients with insulin dependent diabetes type I.

  Medical Journal of MUMS 1999; 81:54-57 (Persian).

· Poster presentation; Cytokine gene polymorphism in patients with HTLV-I associated myelopathy tropical spastic paraparesis.

  BSI, December 2000, Harrogate, U.K.

· Poster presentation: Association of HLA-DR and risk of HAM/TSP in HTLV-I infected individuals. 10th International

  Conference of HTLV-I, July 2001, Dublin, Ireland.

· Poster presentation: Novel polymorphisms in GM-CSF. December 2001, BSI, Harrogate, U.K.

· Oral presentation: Is there association between GM-CSF gene polymorphism and phenotypic variation in GM-CSF production.

  5th Iranian Congress of Allergy and Immunology, May 2004, Mash-had, Iran.

· Poster presentation: Association of a novel single nucleotide polymorphism in the human perforin gene with the outcome

 of HTLV-I infection in patients from northeast Iran (Mash-had).  12th International Congress of Immunology and 4th

 Annual Conference of FOCIS. July 2004, Montreal, Canada.

Membership
 in Societies

· Iranian Society of Allergy and Immunology

· British Society of Immunology (BSI)

 

 

تاريخ بروز رساني : يكشنبه 15/10/87 ساعت 18:50

Mashhad University of Medical Sciences Contact Details:
Main address: University St., Ghoraishy Building 91375-345 Mashhad, Iran ,
Tel:( 98 511) 841 2081-5 , Fax:( 98 511) 8430249 , E-mail: Info(at)mums.ac.ir Members: - Schools and Hospitals School: Dentistry , School: Health , School: Medicine , School: Nursing & Midwifery , School: Paramedical , School: Pharmacy , School: Traditional Medicine , Hospital: Dr.Sheikh , Hospital: Dr.Shariati , Hospital: Emam Reza , Hospital: Ghaem , Hospital: Hashemi Nezhad , Hospital: Ibn-e-Sina , Hospital: Khatam-al-Anbia , Hospital: Montaserie , Hospital: Ommul-Banin , Hospital: Omid , Hospital: Shahid Kamyab , Hospital: Taleghani , History: Mashhad Faculty of Medicine was officially opened on Nov. 23, 1949 by Dr Zanganeh, the minister of culture. The school started out with 61 students, one associate professor and seven tutors. In 1956, when the school of Arts opened, the two schools merged to form the University of Mashhad. In 1989, the faculties offering Medical Sciences' degrees across the country separated from the Ministry of Culture and Higher Education. New emerging Medical Universities have gone under management of Ministry of Health, Treatment and Medical Education. Thus the original University of Mashhad was divided into two independent universities: "Ferdowsi University of Mashhad" and "Mashhad University of Medical Sciences'. Mashhad University of Medical Sciences operates at present with 8 faculties, 32 hospitals, 179 rural and 147 urban health centers. It covers an enormous area stretching from the north east to the central parts of the country, which makes it the largest university of Medical Sciences providing health care and treatment services. With 597 teaching staff, 1645 MDs with different specialties, 138 dentists, 123 pharmacists and 25, 402 employees, the university provides health care and medical services to the area's large population as well as to over 25 million tourists a year.

مشهد، میدان بوعلی، پژوهشکده بوعلی، مرکز تحقیقات ایمونولوژی تلفن: 5-7112611 0511 نمابر: 7112596 0511
پست الکترونیک: IRC@mums.ac.ir
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