دكتر هوشنگ رفعت پناه (MD, PhD ایمونولوژی)
عضو هیئت علمی گروه ایمونولوژی
آدرس: مشهد، میدان بوعلی، پژوهشکده بوعلی، مرکز تحقیقات ایمونولوژی، بخش ایمونوژنتیک و کشت سلولی
تلفن: 5-05117112611 و 05118012762
1999-2003 PhD in Immunology
·Department of Immunology, The University of Manchester
·Title: Immunogenetic analysis of patients with HTLV-I (human T lyphotropic virus type I) infection: associations with HLA, cytokine and Perforin gene polymorphisms
·Project: Investigation the hypothesis that genetic factors may account for the differences in the outcome of HTLV-I infection, namely HTLV-I carrier status or HTLV-associated myelopathy/tropical spastic paralysis (HAM/TS).
1992-1994 MSc in Immunology
·Dept of Immunology, Mash-had University of Medical Sciences, Mash- had, Iran
·Dissertation project: Association between HLA-DR and insulin dependent diabetes type
1983-1987 BSc. in laboratory sciences
Iran University of Medical Sciences, Tehran, Iran.
2003-Present Assistant professor of Immunology
· Dept of Immunology, Ghaem Hospital, Mash-had University of Medical Sciences, Mash-had-Iran.
· Teaching Immunology to undergraduate and postgraduate students.
· I supervised three Master students, and two fellowship theses. In each case this involved assisting in project management, development and completion.
· I was awarded three grants from the chancellor of research, Mash-had University of Medical Sciences. The aim of these projects was to understand the role of Immunogenetic factors in human T lymphotropic virus type I (HTLV-I) and hepatitis B virus.
· Several publications resulted from these work.
· Head of HTLV-I Research lab,
1994-1998 Lecturer of Immunology
· Dept of Immunology, Ghaem Hospital Mash-had university of Medical Sciences, Mash-had, Iran.
Ghaem Hospital, Mash-had University of Medical Sciences, Mash-had, Iran.
1987-1992 Teaching assistant
· Dept of Immunology, Ghaem Hospital, Mash-had University of Medical Sciences, Mashhad-Iran.
· Human T lymphotropic virus type (HTLV-I) is associated with HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T-cell leukaemia (ATL). Fewer than 2% of HTLV-I-infected individuals develop HAM/TSP. The different outcome of HTLV-I infection may be explained by the existence of viral agents, genetic background or even environmental factors. My research aim was to study the correlation between n cytokine gene polymorphisms, mainly Th1 and Th2, in Iranian patients with HAM/TSP, asymptomatic HTLV-I carriers and healthy controls. We also analysed the influence of HLA class II, RB1 alleles and class I HLA-A2, A30, Cw8 and B54 alleles in all three groups. I screened the promoter and first intron of the perforin gene, as a key factor in elimination of viral-infected cells, to determine novel polymorphisms. A novel polymorphism at position +418 relative to the transcription start site was detected. My research output from my PhD studies are summarized in the publication section (please see below).
I mainly investigated the role of cytokines gene polymorphism, HLA and pefrorin in HTLV-I infection individuals. My PhD research involved the following laboratory techniques: flow cytometry/immuno-fluorescent staining, cell culture, cell sorting using micro-beads, PCR, SSCP, RT-PCR, cDNS synthesis and sequencing, SNP genotyping techniques, SDS-page and agarose gel electrophoresis, western blotting, and the use of radioactive isotopes (gamma radiation), DNA cloning, cell line transfection, protein assay and gel shift assay.
· I have knowledge of all Microsoft office programs and whilst at Manchester university attended advanced courses in Excel, PowerPoint and Word. I have a good knowledge in Bioinformatics and experienced in the use of different web sites in this field. I am familiar in a range of statistic software packages including SPSS and STATA.
· Rafatpanah H, Pravica V, Farid R, Tabatabaei A, Ollier A, Poulton K, Thomson W, Hutchnison IV. Association between
HLA-DRB*1 and HLA-Cw*08 and outcome following HTTLV-I infection (submitted to International Journal of Immunogenetics).
· Rafatpanah H, Pravica V, Farid R, Abbaszadegan MR, Tabatabaei A, Goharjoo A, Hutchinson IV.
Association of IL-10 gene polymorphisms and HTLV-I infection in northeast Iran (Mash-had) (submitted).
· Reza Farid, Ramin Ghasemi, Mahmood Baradaran-Rahimi, Farahzad Jabbari, Javad Ghaffari, and Houshang Rafatpanah.
Evaluation of Six Years Allergen Immunotherapy in Allergic Rhinitis and Allergic Asthma. IJAAI, 2006; 5: 29-31.
· Faridhosseni R.., Ghaffari J., Rafatpanah H., Jabbary F., Taghavi M., Shakery M.T., Thyroid Auto antibodies in Chronic Urticaria.Medical Journal of MUMS, 2006; 48:373-378 (Persian).
· Farid R, Ghafari J, Parizadeh M, Miri S, Rafatpanah H. Prevalence of HTLV-I infection in Neishabour-Iran.
Medical Journal of MUMS 2005; 47:417-424 (Persian).
· R. Farid , Shirdel , M. Etemadi , H. Rafatpanah, H. Baradaran , F. Farid, B. Nikbin Phylogenetic of Human T-cell
Lymphotropic Virus Type I in Iranians Born in Mashhad. AIM 1999; 2:20-24.
· Iranian Society of Allergy and Immunology
· British Society of Immunology (BSI)
تاريخ بروز رساني : يكشنبه 15/10/87 ساعت 18:50