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mialdvox
ارسال : يكشنبه 20/01/96 ساعت 12:53

عضو
ﮔﺮﻭﻫﻰ ﺍﺯ ﭘﮋﻭﻫﺸﮕﺮﺍﻥ ﭼﻴﻨﻰ ﺑﺮﺍﻯ ﻧﺨﺴﺘﻴﻦ ﺑﺎﺭ، ﺳﻠﻮﻝ ﻫﺎﻳﻰ ﺭﺍ ﺑﻪ ﺑﺪﻥ ﺍﻧﺴﺎﻥ ﺗﺰﺭﻳﻖ ﻛﺮﺩﻩ ﺍﻧﺪ ﻛﻪ ﺣﺎﻭﻯ ژﻥ ﻫﺎﻳﻰ ﺍﺳﺖ ﻛﻪ ﺑﺎ ﺍﺳﺘﻔﺎﺩﻩ ﺍﺯ ﺭﻭﺵ ﺍﻧﻘﻼﺑﻰ «CRISPR-Cas9» ﺩﺳﺖ ﻛﺎﺭﻯ ﺷﺪﻩ ﺍﻧﺪ. ﺩﺭ ﺷﺮﺍﻳﻄﻰ ﻛﻪ ﭘﮋﻭﻫﺸﮕﺮﺍﻥ ﺁﻣﺮﻳﻜﺎﻳﻰ ﺩﺭﮔﻴﺮ ﺟﺪﺍﻟﻰ ﺣﻘﻮﻗﻰ ﺑﺮ ﺳﺮ ﺣﻖ ﻣﺎﻟﻜﻴﺖ ﺍﺑﺪﺍﻉ ﺍﻳﻦ ﺭﻭﺵ ﻫﺴﺘﻨﺪ، ﻣﻮﻓﻘﻴﺖ ﭘﮋﻭﻫﺸﮕﺮﺍﻥ ﭼﻴﻨﻰ ﻣﻰ ﺗﻮﺍﻧﺪ ﺑﻪ ﺁﻏﺎﺯ ﺭﻗﺎﺑﺘﻰ ﮔﺴﺘﺮﺩﻩ ﺩﺭ ﻋﺮﺻﻪ ﻯ ﺯﻳﺴﺖ ﭘﺰﺷﻜﻰ ﻣﺸﺎﺑﻪ ﺭﻗﺎﺑﺖ ﻓﻀﺎﻳﻰ ﺍﺗﺤﺎﺩ ﺟﻤﺎﻫﻴﺮ ﺷﻮﺭﻭﻯ ﻭ ﺍﻳﺎﻻﺕ ﻣﺘﺤﺪﻩ ﺩﺭ ﺩﻭﺭﺍﻥ ﺟﻨﮓ ﺳﺮﺩ ﻣﻨﺠﺮ ﺷﻮﺩ. ﭘﮋﻭﻫﺸﮕﺮﺍﻥ ﭼﻴﻨﻰ ﺑﻪ ﺳﺮﭘﺮﺳﺘﻰ ﺩﻛﺘﺮ «ﻟﻮ ﻳﻮ»، ﺍﺳﺘﺎﺩ ﺳﺮﻃﺎﻥ ﺷﻨﺎﺳﻰ ﺩﺍﻧﺸﮕﺎﻩ ﺳﻴﭽﻮﺍﻥ، ﺭﻭﺯ 28 ﺍﻛﺘﺒﺮ (7 ﺁﺑﺎﻥ) ﺍﻳﻦ ﺳﻠﻮﻝ ﻫﺎﻯ ﺩﺳﺖ ﻛﺎﺭﻯ ﺷﺪﻩ ﺭﺍ ﺑﻪ ﺑﺪﻥ ﺑﻴﻤﺎﺭﻯ ﺗﺰﺭﻳﻖ ﻛﺮﺩﻧﺪ ﻛﻪ ﺍﺯ ﺳﺮﻃﺎﻥ ﺗﻬﺎﺟﻤﻰ ﺭﻳﻪ ﺭﻧﺞ ﻣﻰ ﺑﺮﺩ.


ﺩﺭ ﺍﻳﻦ ﺭﻭﺵ، ﭘﮋﻭﻫﺸﮕﺮﺍﻥ ﺳﻠﻮﻝ ﻫﺎﻯ ﺍﻳﻤﻨﻰ ﺭﺍ ﺍﺯ ﺧﻮﻥ ﺑﻴﻤﺎﺭ ﺟﺪﺍ ﻛﺮﺩﻧﺪ ﻭ ﺑﺎ ﺍﺳﺘﻔﺎﺩﻩ ﺍﺯ ﺭﻭﺵ CRISPR-Cas9 ژﻧﻰ ﺭﺍ ﺩﺭ ﺁﻥ ﻫﺎ ﻏﻴﺮﻓﻌﺎﻝ ﻛﺮﺩﻧﺪ. ﺩﺭ ﺭﻭﺵ ﻛﺮﻳﺴﭙﺮ ﺍﺯ ﺁﻧﺰﻳﻤﻰ ﺍﺳﺘﻔﺎﺩﻩ ﻣﻰ ﺷﻮﺩ ﻛﻪ DNA ﺭﺍ ﺩﺭ ﻧﻘﺎﻁ ﻣﺸﺨﺺ ﺷﺪﻩ ﺑﺮﺵ ﻣﻰ ﺩﻫﺪ. ﺑﺮﺍﻯ ﺷﻨﺎﺳﺎﻳﻰ ﺍﻳﻦ ﻧﻘﺎﻁ ﺧﺎﺹ ﺍﺯ ﺭﺍﻫﻨﻤﺎﻯ ﻣﻮﻟﻜﻮﻟﻰ ﺍﻯ ﺍﺳﺘﻔﺎﺩﻩ ﻣﻰ ﺷﻮﺩ ﻛﻪ ﻣﻰ ﺗﻮﺍﻥ ﺁﻥ ﺭﺍ ﺑﻪ ﺩﻗﺖ ﺑﺮﻧﺎﻣﻪ ﺭﻳﺰﻯ ﻛﺮﺩ. ﭘﺲ ﺍﺯ ﺑﺮﺵ ﺯﺩﻥ DNA ﻭ ﺟﺪﺍ ﻛﺮﺩﻥ (ﻳﺎ ﺍﻓﺰﻭﺩﻥ ﺭﺷﺘﻪ ﻯ ﺩﻟﺨﻮﺍﻩ)، ﭘﮋﻭﻫﺸﮕﺮﺍﻥ ﺩﻭ ﺳﺮ ﺟﺪﺍﺷﺪﻩ ﺭﺷﺘﻪ ﻯ ﻣﺎﺭﭘﻴﭽﻰ ﺭﺍ ﺑﻪ ﻫﻢ ﻣﻰ ﭼﺴﺒﺎﻧﻨﺪ ﻭ ﺑﻪ ﻣﻮﻟﻜﻮﻝ DNA ﺟﺪﻳﺪ ﻣﻰ ﺭﺳﻨﺪ. ﻛﺪﻫﺎﻯ ژﻧﺘﻴﻜﻰ ﻏﻴﺮﻓﻌﺎﻝ ﺷﺪﻩ ﺩﺭ ﺍﻳﻦ ﺁﺯﻣﺎﻳﺶ ﻣﺮﺑﻮﻁ ﺑﻪ ﭘﺮﻭﺗﺌﻴﻦ «PD-1» ﺑﻮﺩ ﻛﻪ ﻣﻌﻤﻮﻻ ﺑﻪ ﺗﻮﻗﻒ ﭘﺎﺳﺦ ﺍﻳﻤﻨﻰ ﮔﻠﺒﻮﻝ ﻫﺎﻯ ﺳﻔﻴﺪ ﻣﻨﺠﺮ ﻣﻰ ﺷﻮﺩ. ﺍﻳﻦ ﻫﻤﺎﻥ ﮔﻴﺮﻧﺪﻩ ﺍﻯ ﺍﺳﺖ ﻛﻪ ﺳﻠﻮﻝ ﻫﺎﻯ ﺳﺮﻃﺎﻧﻰ ﺑﺎ ﺳﻮءﺍﺳﺘﻔﺎﺩﻩ ﺍﺯ ﺁﻥ، ﺍﺯ ﭼﺸﻢ ﺳﻴﺴﺘﻢ ﺍﻳﻤﻨﻰ ﺑﺪﻥ ﺩﻭﺭ ﻣﻰ ﻣﺎﻧﻨﺪ ﻭ ﺑﻪ ﺭﺍﺣﺘﻰ ﺩﺭ ﺑﺪﻥ ﭘﺨﺶ ﻣﻰ ﺷﻮﻧﺪ. ﭘﮋﻭﻫﺸﮕﺮﺍﻥ ﭘﺲ ﺍﺯ ﺧﺎﻣﻮﺵ ﻛﺮﺩﻥ ﺍﻳﻦ ژﻥ، ﺳﻠﻮﻝ ﻫﺎﻯ ﺟﺪﻳﺪ ﺭﺍ ﺗﻜﺜﻴﺮ ﻭ ﺁﻥ ﻫﺎ ﺭﺍ ﺑﻪ ﺑﺪﻥ ﺑﻴﻤﺎﺭ ﺗﺰﺭﻳﻖ ﻛﺮﺩﻧﺪ. ﺍﻳﻦ ﺑﻴﻤﺎﺭ ﺍﺯ ﻣﺘﺎﺳﺘﺎﺯ ﺳﺮﻃﺎﻥ «ﺳﻠﻮﻝ ﻫﺎﻯ ﻏﻴﺮﻛﻮﭼﻚ ﺭﻳﻪ» ﺭﻧﺞ ﻣﻰ ﺑﺮﺩ ﻭ ﭘﮋﻭﻫﺸﮕﺮﺍﻥ ﺍﻣﻴﺪﻭﺍﺭﻧﺪ ﺳﻠﻮﻝ ﻫﺎﻯ ﺳﺮﻃﺎﻧﻰ ﺍﻭ ﺭﺍ ﺑﻪ ﻛﻤﻚ ﺳﻴﺴﺘﻢ ﺍﻳﻤﻨﻰ ﺑﺪﻥ ﺧﻮﺩﺵ ﺳﺮﻛﻮﺏ ﻛﻨﻨﺪ. ﺩﺭ ﺍﻳﻦ ﺩﺭﻣﺎﻥ ﺁﺯﻣﺎﻳﺸﻰ، 10 ﺑﻴﻤﺎﺭ ﺷﺮﻛﺖ ﺩﺍﺭﻧﺪ ﻭ ﺩﻭ ﺗﺎ ﭼﻬﺎﺭ ﺗﺰﺭﻳﻖ ﺳﻠﻮﻝ ﻫﺎﻯ ﺩﺳﺖ ﻛﺎﺭﻯ ﺷﺪﻩ ﺑﺮﺍﻯ ﻫﺮ ﺑﻴﻤﺎﺭ ﭘﻴﺶ ﺑﻴﻨﻰ ﺷﺪﻩ ﺍﺳﺖ.

ﻏﻴﺮﻓﻌﺎﻝ ﺳﺎﺯﻯ ﮔﻴﺮﻧﺪﻩ ﻫﺎﻯ ﭘﺮﻭﺗﺌﻴﻨﻰ PD-1 ﻳﻜﻰ ﺍﺯ ﺟﺪﻳﺪﺗﺮﻳﻦ ﺭﻭﺵ ﻫﺎﻯ ﻣﻘﺎﺑﻠﻪ ﺑﺎ ﺳﺮﻃﺎﻥ ﺍﺳﺖ (ﮔﺰﺍﺭﺵ ﺧﺒﺮﻯ ﺷﻤﺎﺭﻩ ﻯ 152 ﺩﺍﻧﺴﺘﻨﻴﻬﺎ ﺭﺍ ﺑﺨﻮﺍﻧﻴﺪ) ﻭ ﺑﻪ ﻧﺘﺎﻳﺞ ﺩﺭﺧﺸﺎﻧﻰ ﺩﺭ ﺑﻬﺒﻮﺩ ﻋﻼﺋﻢ ﻭ ﺣﺘﻰ ﻧﺎﺑﻮﺩﻱ ﺳﻠﻮﻝ ﻫﺎﻯ ﺳﺮﻃﺎﻧﻰ ﺩﺭ ﺑﻴﻤﺎﺭﺍﻧﻰ ﻣﻨﺠﺮ ﺷﺪﻩ ﺍﺳﺖ ﻛﻪ ﺩﺭ ﭘﻴﺸﺮﻓﺘﻪ ﺗﺮﻳﻦ ﻣﺮﺍﺣﻞ ﺳﺮﻃﺎﻥ ﺑﻪ ﺳﺮ ﻣﻰ ﺑﺮﺩﻧﺪ ﻭ ﺍﻣﻴﺪ ﺧﻮﺩ ﺭﺍ ﺑﻪ ﺯﻧﺪﮔﻰ ﺍﺯ ﺩﺳﺖ ﺩﺍﺩﻩ ﺑﻮﺩﻧﺪ. ﺩﺭ ﺭﻭﺵ ﻫﺎﻯ ﻓﻌﻠﻰ ﺍﺯ ﺩﺍﺭﻭ ﺑﺮﺍﻯ ﻏﻴﺮﻓﻌﺎﻝ ﻛﺮﺩﻥ ﺍﻳﻦ ﮔﻴﺮﻧﺪﻩ ﻫﺎ ﺍﺳﺘﻔﺎﺩﻩ ﻣﻰ ﺷﻮﺩ. ﺩﺳﺖ ﻛﺎﺭﻯ ژﻧﺘﻴﻜﻰ ﺳﻠﻮﻝ ﻫﺎﻯ ﺍﻳﻤﻨﻰ ﺑﺪﻥ، ﺭﻭﺵ ﺟﺪﻳﺪﻯ ﺍﺳﺖ ﻛﻪ ﺗﺎﺯﻩ ﻧﺨﺴﺘﻴﻦ ﺁﺯﻣﺎﻳﺶ ﺁﻥ ﺍﻧﺠﺎﻡ ﺷﺪﻩ ﺍﺳﺖ ﻭ ﮔﺬﺷﺖ ﺯﻣﺎﻥ،ﻛﺎﺭﺍﻳﻰ ﺁﻥ ﺭﺍ ﻣﺸﺨﺺ ﺧﻮﺍﻫﺪ ﻛﺮﺩ.

منبع : http://www.sefidak.com

- ويرايش شده توسط : mialdvox


artman
ارسال : سه شنبه 14/06/96 ساعت 12:53

عضو
اینجوری کل سرطان از بذن بیمار خارج میشه؟ینی بیمار دیگه ترس از نور آفتاب نداره و راحت میتونه کنار ساحل آفتابی قدم بزنه؟




پاسخ شما
توپر  ايتاليک  زير خط دار  لينک تصوير  لينک پيوند  عدم در نظر گرفتن کدهاي خاص *يعني چه؟

 

Mashhad University of Medical Sciences Contact Details:
Main address: University St., Ghoraishy Building 91375-345 Mashhad, Iran ,
Tel:( 98 511) 841 2081-5 , Fax:( 98 511) 8430249 , E-mail: Info(at)mums.ac.ir Members: - Schools and Hospitals School: Dentistry , School: Health , School: Medicine , School: Nursing & Midwifery , School: Paramedical , School: Pharmacy , School: Traditional Medicine , Hospital: Dr.Sheikh , Hospital: Dr.Shariati , Hospital: Emam Reza , Hospital: Ghaem , Hospital: Hashemi Nezhad , Hospital: Ibn-e-Sina , Hospital: Khatam-al-Anbia , Hospital: Montaserie , Hospital: Ommul-Banin , Hospital: Omid , Hospital: Shahid Kamyab , Hospital: Taleghani , History: Mashhad Faculty of Medicine was officially opened on Nov. 23, 1949 by Dr Zanganeh, the minister of culture. The school started out with 61 students, one associate professor and seven tutors. In 1956, when the school of Arts opened, the two schools merged to form the University of Mashhad. In 1989, the faculties offering Medical Sciences' degrees across the country separated from the Ministry of Culture and Higher Education. New emerging Medical Universities have gone under management of Ministry of Health, Treatment and Medical Education. Thus the original University of Mashhad was divided into two independent universities: "Ferdowsi University of Mashhad" and "Mashhad University of Medical Sciences'. Mashhad University of Medical Sciences operates at present with 8 faculties, 32 hospitals, 179 rural and 147 urban health centers. It covers an enormous area stretching from the north east to the central parts of the country, which makes it the largest university of Medical Sciences providing health care and treatment services. With 597 teaching staff, 1645 MDs with different specialties, 138 dentists, 123 pharmacists and 25, 402 employees, the university provides health care and medical services to the area's large population as well as to over 25 million tourists a year.

مشهد، خيابان دانشگاه،- صندوق پستی: ۳۴۵ - ۹۱۳۷۵ تلفن: 3852119-0511نمابر: 051138521119 پست الکترونيک: cg@mums.ac.ir
مشهد، بلوار شهید فکوری، حد فاصل میدان شهید آل شهیدی و میدان شهید جوان، شهرک دانش و سلامت، کدپستی 9177899191 صندوق پستی 345، ساختمان زکریا، طبقه اول
تمام حقوق مادی و معنوی این سایت مربوط به دانشگاه علوم پزشکی مشهد می باشد و هرگونه کپی برداری از مطالب آن تنها با ذکر منبع بلامانع است.